Published in Academic Medicine, the paper puts forth a new paradigm for improving medical student mental health, by describing an integrated, multifaceted, preclinical curricular change program implemented at the Saint Louis University School of Medicine. Changes in course content, contact hours, scheduling, grading, electives, learning communities, and required resilience/mindfulness experiences were shown to result in significantly lower levels of depression symptoms, anxiety symptoms, and stress, and significantly higher levels of community cohesion.