Improving the quality of health care requires going beyond the basic standards for health care organizations and formal clinician education. One potential strategy to improve health care quality is credentialing. Progress in credentialing research is currently obstructed by datasets that are both insufficiently accessible and inadequately standardized across credential types and credentialing organizations. To gain an understanding of the impact credentialing has on health care organizations, patients, and clinicians, researchers must have access to data that are standardized, accessible, and up to date, as well as defined and consistently structured. Additionally, data must report on organizations and individuals with and without credentials or credentialing programs. This paper briefly summarizes the role of informatics in building a credentialing research infrastructure and in addressing key issues involved in securing, managing, and using data and information associated with credentialing.