Published in Population Health Management, the following study aimed to determine the relationship between health status and productivity loss and to provide estimates of the business implications of lost work performance. Health risk appraisal responses from over 1 million participants were analyzed to determine productivity loss associated with several common health conditions and health risks. Results were monetized and multiplied by the average number of employees with conditions or risks to illustrate the potential impact of productivity loss to employers. After matching and regression-based adjustments were made, employees with health conditions and at high risk for health problems had productivity costs ranging from $15 to $1601 more per year than similar employees without health conditions/risks.