This quasi-experimental study, published in Medical Teacher, aimed to investigate whether a mind–body medicine (MBM) skills course could reduce perceived stress and increase empathy and self-reflection in medical and nursing students. The MBM course (consisting of experiential sessions of mind–body techniques and group reflections) was piloted among 74 Dutch medical students and 47 Swedish nursing students. The study demonstrated long-term beneficial effects of the MBM course on perceived stress and empathy in medical and nursing students. Participating medical students showed significantly increased empathic concern, increased fantasy, and decreased personal distress compared to controls until 12 months follow-up. Participating nursing students showed significantly decreased levels of perceived stress and decreased personal distress compared to controls until 12 months follow-up.