Against the backdrop of the debate on nature and consequences of work practices on physician well-being for women, this article explores how factors relating to the work–life interface affect well-being of hospital doctors. More specifically, the key aim is to discover discernible gender differences in factors associated with perceptions of job burnout and intentions to quit. The research suggests that female doctors are more likely to experience job burnout than male doctors. The work–life interface is shown to affect well-being of all doctors; however, women tend to rely on different forms of social support from men to alleviate burnout and reduce the likelihood of leaving their job.