The following paper describes the development, implementation and outcomes of the Health Enhancement Program (HEP) at Monash University. Comprised of mindfulness and ESSENCE lifestyle programs, the program is experimentally-based and integrates with the core biomedical sciences, clinical skills and assessment. The results indicated that the program improved overall well-being of medical students with 91% of students reporting application of mindfulness practices, improved student well-being on all in depression, hostility, and psychological domain. The findings suggest that common decline is avoidable. Future research with a control group and more prolonged follow-up assessments is suggested.