This paper, published in Cancer Oncology Nursing Journal, details a descriptive exploratory qualitative research study that investigated the experience of compassion fatigue (CF) in Canadian clinical oncology registered nurses (RNs). Participants completed a questionnaire and wrote a narrative describing an experience with CF and submitted these through a secure research website. Participants had limited knowledge about CF, about lack of external support, and that insufficient time to provide high quality, care may precipitate CF. The gap between quality of care nurses wanted to provide and what they were able to do, compounded by coexisting physical and emotional stress, worsened CF. CF was lessened by colleague support, work-life balance, connecting with others, acknowledgement, and maturity and experience. Outcomes of CF included profound fatigue of mind and body, negative effects on personal relationships, and considering leaving the specialty.