The current state of diversity within the United States medical workforce does not reflect representative numbers of the Black male population. Research data continues to reveal continuing trends in the areas of discrimination, incarceration, health disparities and mortality with respect to Black males. The lack of increase in Black male medical school applications and matriculation contrasted by the continuing trends mentioned above illustrates that there is in fact an American crisis. Published by the National Academy of Medicine, the authors of this discussion paper present here a call to arms, to address the need of African American men in medicine. The absence of Black males in medical school represents an American crisis that threatens efforts to effectively address health disparities and excellence in clinical care. This disturbing trend is in need of more empirical examination of medical school data specifically in the areas of: qualification barriers, race/ethnic classification and the impact of diversity on quality of health care in the U.S.