Published in the Journal of General Internal Medicine, the following study was designed to gain a more nuanced understanding of work–life balance issues from the perspective of a large and diverse group of faculty clinician-researchers and their mentors. Five themes emerged related to work–life balance: (1) the challenge and importance of work–life balance for contemporary physician-researchers, (2) how gender roles and spousal dynamics make these issues more challenging for women, (3) the role of mentoring in this area, (4) the impact of institutional policies and practices intended to improve work–life balance, and (5) perceptions of stereotype and stigma associated with utilization of these programs.