Mindful clinical practice, as described in a chapter of The Wiley Blackwell Handbook of Mindfulness, is associated with mindful attitudes, such as adopting multiple perspectives on a clinical situation, attention to context, considering facts as conditional, seeing novelty in familiar situations, modulating reactivity and considering diagnostic categories as provisional. The chapter provides evidence and illustrations on the link between mindfulness, greater resilience and well-being in the healthcare workforce, and the potential to reverse the trends toward burnout, attrition and alienation. Furthermore, it focuses on how mindful practice might be promoted through institutional and individual efforts involving trainees and practicing clinicians.