Physician distress often spills over into their personal lives and manifests itself into depression, anxiety, substance abuse, divorce, broken relationships, and disillusionment. Shanafelt delves into work-home interference and the standards for well-being in physicians through a thorough review of psychology and burnout literature. Furthermore, the focus transitions to practical suggestions for physicians and implications for academic medicine, health maintenance organizations, and physician organizations as a call to action for research and change.