This study examines the links between nurses’ experience of progessional burnouts and their work environment, specifically investigating the interrelationships among aspects of complex organizational settings. Using hospital-based nurses in Canada, the authors found support for a structural nursing worklife model, linking the five worklife factors used to define a fundamental role for nursing leadership, in determining the quality of worklife regarding policy involvement, staffing levels, support for a nursing model of care, and physician-nurse relationships. The analysis supported a direct path (negatively weighted) from staffing to emotional exhaustion and a direct path (positively weighted) from nursing model of care to personal accomplishment.