This reflection piece discusses interventions to address both avoidable and unavoidable occupational suffering among physicians. It distinguishes between the two as one that’s inherent in the physician’s role (unavoidable) and one that is the result of system failures that are preventable (avoidable). While resiliency training may help in addressing inevitable suffering, it is not the right solution to organizational structures that lead to avoidable suffering. Building an evidence base for improving work systems is vitally essential in mitigating occupational adversity in health care.