Published in International Journal of Mental Health Nursing, this review summarizes up-to-date knowledge of physician burnout and develops a framework to reverse its negative impact, decrease its prevalence, and implement effective organizational and personal interventions. The study concludes, with prevalence now exceeding 50%, burnout is the unintended result of disruptive changes in society at large, the medical profession, and the healthcare system. Two effective strategies identified are aligning personal and organizational values and enabling physicians to devote 20% of work activities to the meaningful parts of their medical practice.