This chapter in the Integrating Psychiatry and Primary Care book series (IPPC) emphasizes that enhancing individual resiliency can inadvertently shift sole responsibility onto physicians. The emphasis on organizational interventions ought to be on (1) work overload relative to the time available, (2) insufficient autonomy with loss of both discretionary time and input into decisions affecting patient care, (3) a non-supportive interpersonal work environment, (4) incentives tied to productivity, based on increased fiscal and performance monitoring, with diminishing respect and appreciation, (5) perceived organizational injustice, and (6) misaligned values between physicians and their organizations. Local interventions should be uniquely crafted by physicians based on the work factors they identify in their clinical units. Interventions should be supported to uphold the three-fold aims of leadership: healthcare of populations, enhancing their patients’ experience of care, and reducing costs.