Nurse suicide threatens the sustainability of our health system and the care and safety of our patients. But no one is tracking it. Although burnout, depression, and suicide in nurses are beginning to be recognized as a significant threat to our health care system, we cannot report the rate at which nurses die by suicide because this data is not accurately tracked. In this National Academy of Medicine discussion paper, authors aim to shed light on the seemingly silent issue of nurse suicide by sharing their insights and the insights of those who have been personally affected by the loss of a colleague, relative, or friend. The issue of nurse suicide has often been largely ignored. Discover why culture change is needed now and how researchers are aiming to break the silence.