The following review evaluates both the prevalence of burnout and depression, as well as the perception of such conditions, through a cross-sectional survey of 92 residents and 55 attendings. Findings show that prevalence of burnout and depression was high among attendings and residents, yet 51% of residents and 75% of attendings underestimated the prevalence of these conditions. Discrepancies in actual and perceived levels of burnout and depression may hinder wellness interventions. Increasing understanding of these perceptions may therefore offer an opportunity to develop practical solutions.