In the following mixed-methods study of medical students, Kraemer et al. (a) describe changes in distress tolerance after completion of a mind-body skills training; (b) examine relationships between psychological variables and distress tolerance; and (c) report students’ perceptions of the mind-body skills training with an emphasis on personal and professional functioning. Mind-body skills training elucidated modest improvement in all distress tolerance subscales and improved perceived ability to tolerate affective distress. Overall, improvements in psychological symptoms were associated with improvements in distress tolerance for the group receiving mind-body skills training. The authors posit that the preliminary findings support mind-body skills training improves psychological well being and suggest more methodologically rigorous designs.