This study assesses the general mental well-being among hospital clinicians in Kingston, Jamaica. Surveys, burnout tools, and focus group discussion findings reported a total of 27.4% of clinicians met criteria for probable cases of mental distress. Caseness is associated with years of professional experience, work-related and non-work-related stress, serious financial difficulties and fears of coming to work. High work-related stress reduced the risk of being classified a case, suggesting that work may have been therapeutic. Focus group discussions suggested that non-work stress was related to financial difficulties, commuting and child care, especially among nurses. Interventions to improve general mental well-being should be targeted at new employees and should address child care, commuting and financial management.