Published in the Mayo Clinic Proceedings, the following article evaluates the impact of organizational leadership on the professional satisfaction and burnout of individual physicians working for a large health care organization. Authors surveyed physicians and scientists working for a large health care organization in October 2013. Validated tools were used to assess burnout. Physicians also rated the leadership qualities of their immediate supervisor in 12 specific dimensions on a 5-point Likert scale. On multivariate analysis adjusting for age, sex, duration of employment at Mayo Clinic, and specialty, each 1-point increase in composite leadership score was associated with a 3.3% decrease in the likelihood of burnout and a 9.0% increase in the likelihood of satisfaction of the physicians supervised. These findings have important implications for the selection and training of physician leaders and provide new insights into organizational factors that affect physician well-being.