Women now account for an increasingly large percentage of medical school students and practicing physicians, yet there is still a scarcity of research on how gender-related differences can affect clinician burnout and well-being. Recognizing gender-related differences is critical in designing effective strategies to improve clinician well-being and to identify, treat, and prevent burnout. This NAM Perspectives Discussion Paper examines how gender-related differences can manifest, and some strategies for ensuring well-being for all health professionals.