The Triple Aim—enhancing patient experience, improving population health, and reducing costs—is widely accepted as a compass to optimize health system performance. Clinician burnout is associated with lower patient satisfaction, reduced health outcomes, and it may increase costs. Thus, burnout imperils the Triple Aim. This article, published in Annals of Family Medicine, recommends that the Triple Aim be expanded to a Quadruple Aim, adding the goal of improving the work life of health care providers, including clinicians and staff.