This study in Mayo Clinic Proceedings sought to evaluate the prevalence of burnout and satisfaction with work-life balance in physicians and US workers in 2014 relative to 2011. The authors surveyed both US physicians and a probability-based sample of the general US population. Burnout was measured using validated metrics, and satisfaction with work-life balance was assessed using standard tools. The authors found that burnout among physicians increased from 2011 to 2014: 54.4% of the physicians reported at least 1 symptom of burnout in 2014 compared with 45.5% in 2011.