Oncology nurses are susceptible to the development of secondary traumatic stress due to their continuous interaction with cancer patients who often have traumatic experiences associated with their illness. The following dissertation examines the variables that contribute to the development of Secondary Traumatic Stress in oncology nurses. Workplace/workload variables explain a significant amount of variance in secondary traumatic stress. Specifically, number of deaths was negatively associated with general secondary traumatic stress, intrusion, avoidance, and arousal. Support and preparation variables were found to be the most significant predictors of secondary traumatic stress.