Published in Critical Care Medicine, this study is a cross-sectional online survey of pediatric critical care physicians across the United States. It aims to estimate the prevalence of physical burnout, psychological distress and its association with selected personal and practice characteristics among pediatric critical care physicians, as well as evaluate the relationship between burnout and psychological distress. Findings show that two thirds of the physicians with severe burnout met the screening criteria for psychological distress that suggests possible common mental disorders. Significant percentages of physicians experiencing burnout and considering to leave the profession has major implications for the critical care workforce.