The following viewpoint, published in JAMA, describes an effort undertaken in a network of North American hospitals and clinics to explore the types and magnitudes of waste in the form of administrative burden and complexity at the front lines of care. Members of the Leadership Alliance (Alliance), a network which comprises approximately 40 North American hospitals, associations, and other care systems were encouraged to ask their patients and staff a simple question: “If you could break or change any rule in service of a better care experience for patients or staff, what would it be?” The viewpoint discusses the rules nominated by participants that were perceived to provide little or no value to patients and staff.