Published in JAMA, the following study aimed to determine the association of fatigue and distress with self-perceived major medical errors among resident physicians using validated metrics. Of the 356 participants providing error data, 139 reported making at least 1 major medical error during the study period. In univariate analyses, there was an association of subsequent self-reported error with the Epworth Sleepiness Scale score and fatigue score. Subsequent error was also associated with burnout, a positive depression screen, and overall QOL. Higher levels of fatigue and distress are independently associated with self-perceived medical errors.