Published in Academic Medicine, this paper’s objective was to determine which resident-identified factors are associated with the presence and absence of burnout. Pessimism was the only burnout factor associated with all three burnout scales. Use of prescription medications was the only wellness factor associated with all three burnout scales, indicating low burnout. Program directors should consider multiple factors associated with burnout when designing interventions. The aim should be to bolster wellness factors and minimize stressors in an effort to reduce burnout.