The high prevalence of burnout in Emergency Medicine has a significant impact on quality of care and workforce retention. This study determined whether higher religion/spirituality is associated with a lower prevalence of burnout and improved secondary outcomes (history of malpractice lawsuits and maladaptive behaviors) for EM physicians. The data indicated prevalence of burnout to be 27%. No significant associations were observed between burnout and religion/spirituality indicators. Maladaptive behaviors (smoking, drinking, and substance use) and history of medical malpractice were less prominent among physicians reporting some religion/spirituality measures. The preliminary evidence in this study suggest further research.