The following study contains a quantitative/qualitative analysis of survey responses from US neurologists. The purpose of the surveys was to examine age and sex differences in burnout, career satisfaction, and well-being. Questions in the survey covered personal and professional characteristics along with standardized instruments to measure burnout and career satisfaction. Results found higher rates of burnout and lower rates of career satisfaction in women than in men. The relationship of burnout with age combined with demographics of respondents was significant to this result. The differences in burnout, career satisfaction, and well-being by age and between men and women neurologists suggest that efforts to mitigate burnout would be most effective if they are personalized to reflect the physician’s age, career level, sex, and home life.