The Health Policy Institute of Ohio collaborated with The Ohio State University College of Nursing Helene Fuld Health Trust National Institute for Evidence-based Practice in Nursing and Healthcare to create A Call to Action: Improving Clinician Well-Being and Patient Care and Safety. The Call to Action outlines the bi-directional relationship between clinician well-being and patient care, calls attention to the health problems clinicians face related to burnout, and highlights the need for a comprehensive approach to prevention, treatment, and recovery efforts. As part of this approach, state policymakers and healthcare leaders have an important role in implementing evidence-informed policies and practices such as advancing positive organizational culture, promoting wellness programs, reducing stigma toward seeking mental health treatment, increasing access to mental health services, and monitoring the data on student and clinician wellness.