The following study was conducted in two hospitals in Croatia and Macedonia to examine the differences in burnout, work demands, and teamwork between Croatian and Macedonian nurses. Croatian nurses reported higher levels of depersonalization, organizational and emotional work demands, while Macedonian nurses reported higher levels of physical work demands and team work. Emotional work demands predicted increased emotional exhaustion and depersonalization, while team work negatively predicted emotional exhaustion and depersonalization in both groups. This study confirms the need for balanced job demands and resources interaction in order to prevent burnout in hospital nurses.