According to data from the Bureau of Justice Statistics, an estimated 3.8 million nonfatal, violent victimizations occurred in 2010 alone, based on a national survey of persons age 12 or older. In the same year, homicide was ranked as the second leading cause of death for 15 to 24 year-olds according to the National Vital Statistics System. And the Department of Health and Human Services estimated that, in 2011, 1.6 million referrals were screened for child abuse or neglect. Despite encouraging reports of reductions in violence in the United States, these data demonstrate that millions of individuals, including children, are subjected to violence every year. The magnitude of the prevalence of violence underscores the need to implement programs that have demonstrated effectiveness to prevent violence. Fortunately, the evidence for strategies, programs, and interventions to prevent violence has grown during the last few decades, and the ability to access this evidence has been transformed by technological developments. However, there are challenges when implementing evidence-based violence prevention programs. This discussion paper identifies progress in the growth and accessibility of the evidence base for violence prevention and highlights several challenges in implementing evidence-based interventions.