In “Essential Stewardship Priorities for Academic Health Systems,” the CEOs of five leading academic centers – BJC HealthCare, Duke University Medical Center, Henry Ford Health System, Partners HealthCare System, and UCLA Health System draw from experiences built on the unique strengths and roles of their institutions to develop the ten essential priorities for Academic Health Systems in navigating the evolving health care terrain. Recognizing that Academic Health Systems (AHSs) must adapt in order to continue to fulfill their responsibilities as the leaders of research, education, and care delivery, the authors put forth the list of priorities as a grounding framework for developing new and innovative models of care, re-engineering education programs, and streamlining the bench-to-bedside translation of biomedical research. Developing a diverse and well-coordinated health workforce and increasing collaboration among stakeholders will be a central component to AHSs ability to steward a continuously learning and improving health system. Accompanying this Discussion Paper is the related Academic Health System Case Material providing illustrative examples of the ways in which these institutions are working to improve care innovation and values, operate at the frontier of biomedical science, strengthen workforce culture, competence, and capacity, and build partnerships and leadership. Other institutions are invited and encouraged to submit material from their own experiences, which may be included in later updates to firstname.lastname@example.org.