Action Collaborative on Combatting Substance Use and Opioid Crises
The substance use crisis is complex. Together, we can overcome it.

About the Program
To improve coordination and accelerate the pace of change, the National Academy of Medicine has partnered with more than 80 organizations to form the Action Collaborative on Combatting Substance Use and Opioid Crises. This initiative brings together key stakeholders from the public, private, and nonprofit sectors to collaboratively address critical issues posed by addiction.
The Action Collaborative is committed to proactively driving structural change by developing, curating, and implementing comprehensive, multi-sector solutions designed to reduce substance misuse and improve outcomes for individuals, families, and communities affected by addiction.
Solving this crisis demands a collaborative effort. No single organization, government agency, or sector possesses the necessary expertise and resources to tackle this complex public health crisis alone. By joining forces, we can overcome the challenges of addiction and pave the way for a healthier and safer future for all.
A National Crisis
Every day, an estimated 260 Americans lose their lives to drug-related overdoses, leaving families and communities across the nation devastated.
While the substances involved continue to change, the overdose crisis persists.
To effectively address this evolving public health challenge, our strategies and approaches must also change.
Important Definitions
These are guiding definitions that characterize our work, not official definitions of the NAM.
Substance Misuse
The use of drugs (including opioids), alcohol, or other substances in ways that can adversely affect an individual's health and well-being.
Substance Use Disorder
A treatable health condition marked by challenges in managing substance use despite harmful consequences that affect a person's well-being and quality of life.
Substance Use Crisis
A critical public health challenge characterized by escalating rates of substance misuse and overdose deaths, causing significant health, social, and economic harms for individuals, families, and communities, such as the opioid crisis.
Stigma
Negative societal, structural, and self-imposed beliefs, attitudes, and practices that isolate, shame, and discriminate against people facing substance misuse challenges, impacting their access to treatment, recovery, and support services.
Program Phases
Our Approach
By taking a comprehensive and adaptive approach, incorporating ongoing research, improving access to prevention and treatment, collaborating across sectors, and conducting meaningful community engagement to support those affected by addiction, we can change the course of this devastating crisis, save lives, and forge a healthier future for our nation.
Phase I
In Phase I (2018–2020), the Action Collaborative convened over 60 key entities to address some of the highest-priority elements in the nation’s response to the opioid crisis, including: health professional education and training; pain management guidelines and evidence standards; prevention, treatment, and recovery services; and research, data, and metrics needs. In addressing these focus areas, the Action Collaborative developed tools and resources that: strengthened the continuum of health professional education to prepare clinicians to effectively manage pain and treat opioid use disorder (OUD); highlighted best practices, research gaps, and future priorities for improving pain management practices; identified priorities to support prevention, treatment, and recovery services and helped prepare the nation’s health system to better meet the needs of individuals with OUD; and supported communities and individuals experiencing addiction and pain throughout the COVID-19 pandemic.
Phase II
In Phase II (2020–2022), the Action Collaborative continued to build on its focus areas from Phase I while evolving to address the changing crisis. The Action Collaborative developed a wide range of products, including publications, podcasts, patient-centered resources, and frameworks while also holding strategic convenings such as webinars, workshops, and thematic meetings. Together, the products and convenings from Phase II advanced progress across the Action Collaborative’s focus areas, including challenges posed by COVID-19. The Action Collaborative also began to expand its work to include substances beyond opioids in response to the growing impact of fentanyl and illicit drugs on the overdose crisis. The Action Collaborative’s work informed federal priorities, advanced national research initiatives, supported health system change, and positioned the Action Collaborative to continue leading a unified systems response to the substance use crisis.
Phase III
During Phase III (2022–present), the Action Collaborative is focused on addressing the evolving nature of the substance use and opioid crisis and leading action that will create a sustainable response into the future. To achieve its goals, the Action Collaborative’s Phase III strategy focuses on advancing health equity, catalyzing data-driven implementation efforts, and developing a framework to address future substance use crises. In Phase III, the Action Collaborative will operationalize its work through three interrelated working groups: education, practice, and health systems; prevention, data, and research; and substance use disorder framework.

Telehealth Agenda
Integrating Telehealth and Traditional Care in Chronic Pain Management and Substance Use Disorder Treatment
An Action Agenda for Building the Future State of Hybrid Care
Mapping Our Impact
Systems and Impact Maps
To demonstrate and track impact, we are mapping how the Action Collaborative is driving systems change, contributing to the field, and making a difference. The two maps illustrate the direct impacts we are having through our work products and activities, as well as the critical role the Action Collaborative plays in fostering a coordinated and cohesive systems response to the substance use crisis.

Latest Perspectives
Latest Products
Program Team
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Leadership

Victor J. Dzau, MD, is the President of the National Academy of Medicine (NAM), formerly the Institute of Medicine (IOM). In addition, he serves as Vice Chair of the National Research Council. Dr. Dzau is Chancellor Emeritus and James B. Duke Distinguished Professor of Medicine at Duke University and the past President and CEO of the Duke University Health System. Previously, Dr. Dzau was the Hersey Professor of Theory and Practice of Medicine and Chairman of Medicine at Harvard Medical School’s Brigham and Women’s Hospital, as well as Bloomfield Professor and Chairman of the Department of Medicine at Stanford University.
Dr. Dzau is an internationally acclaimed physician scientist and leader whose work has improved health and medicine in the United States and globally. His seminal work in cardiovascular medicine and genetics laid the foundation for the development of the class of lifesaving drugs known as ACE inhibitors, used globally to treat hypertension and heart failure. Dr. Dzau pioneered gene therapy for vascular disease and was the first to introduce DNA decoy molecules in humans in vivo. His pioneering research in cardiac regeneration led to the Paracrine Hypothesis of stem cell action and his recent strategy of direct cardiac reprogramming using microRNA. He maintains an active NIH-funded research laboratory.
Dr. Dzau is a leader in health and heath policy. At the NAM, he has led important initiatives such as Vital Directions for Health and Health Care, the Action Collaborative on Countering the US Opioid Epidemic, and the Action Collaborative on Clinician Well-Being and Resilience. Under his tenure, the NAM has advanced efforts to improve health equity and address racism throughout its programmatic activities, especially the Culture of Health Program. Most recently, the NAM launched a Grand Challenge in Climate Change and Human Health & Equity to reverse the negative effects of climate change on health and social equity by activating the entire biomedical community, communicating and educating the public about climate change and health, driving changes through research, innovation and policy, and leading bold action to decarbonize the health care sector.
As a global health leader, he helped design and launch the National Academies initiatives on Global Health Risk Framework; Global Health and Future Role of the US; Crossing the Global Quality Chasm and Human Genome Editing. The NAM Global Grand Challenge for Healthy Longevity represents his vision to inspire across disciplines and sectors to coalesce around a shared priority and audacious goal to advance health.
He has led the NAM’s response to COVID-19, which includes numerous committees, reports, consultations and communication on a range of issues including public health, vaccine allocation, health equity and mental health. He has worked tirelessly to engage with the global response to COVD-19 by providing leadership as a member of the Global Preparedness Monitoring Board, co-chair of the G20 Scientific Expert Panel on Global Health Security, Advisor to the G20 High Level Independent Panel on Financing and a principal of the ACT-Accelerator which includes COVAX, the global collaboration for accelerating the development, manufacture and equitable distribution of COVID-19 vaccines.
He is active in advising science and health in US and globally. He has served as a member of the Advisory Committee to the Director of the National Institutes of Health (NIH), chaired the NIH Cardiovascular Disease Advisory Committee and NHLBI Cardiovascular Progenitor Cell Biology Consortium. Currently, he chairs the Cardiovascular Progenitor Cell Translational Consortium. He is a member of the Health and Biomedical Sciences International Advisory Council of Singapore, as well as a board member of the Imperial College Health Partners, UK and the Gairdner Foundation. He chairs the International Scientific Advisory Committee of the Qatar Precision Medicine Institute, the Scientific Boards of the Peter Munk Cardiac Center, University of Toronto and Institute of Cardiovascular and Medical Sciences, University of Glasgow. He served on the Board of Health Governors of the World Economic Forum and chairs its Global Futures Council on Healthy Longevity.
Among his many honors and recognitions are the Max Delbreck Medal from Charite, Humboldt and Max Planck, Germany, the Distinguished Scientist Award from the American Heart Association, Ellis Island Medal of Honor, and the Henry Freisen International Prize. In 2019, he was named an Honorary Citizen of Singapore- the highest level of honor bestowed to a foreign citizen conferred by the President of Singapore. He has been elected to the National Academy of Medicine, the American Academy of Arts and Sciences, the European Academy of Sciences and Arts, UK Academy of Medical Sciences, the Japan Academy, Mexican Academy of Medicine, Chinese Academy of Engineering and Academia Sinica. He has received 16 honorary doctorates.



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Sponsors
The Action Collaborative serves as a neutral platform through which to facilitate dialogue and discussion among representatives from multiple sectors around topics of mutual interest and concern. Individual participating members of the Action Collaborative on Combatting Substance Use and Opioid Crises have disclosed any perceived or actual interests (financial, organizational, professional, or personal in nature) relevant to the activities of the Action Collaborative. Summaries of relevant interests reported can be found here.
Contact Information
Questions?
Contact us at [email protected].