National Academy of Medicine

Expanding the Role of N-of-1 Trials in the Precision Medicine Era: Action Priorities and Practical Considerations

  Heterogeneous responses to the same therapy among individual patients are commonp
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A Proposed Approach for Implementing Genomics-Based Screening Programs for Healthy Adults

The central idea of early disease detection and treatment is essentially simple. However, the path to its succe
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Variant Validity (Selected vs. General Population)

Advances in genome sequencing represent an unparalleled opportunity to examine the genomic landscape of an individual and potentially i
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Analytic Validity of Genomic Testing

The advent of genome sequencing has changed our fundamental understanding of the underlying basis of disease. It has opened up new avenues for dia
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Analytics in Support of Health Care Transformation

We have a good concept of the flawed state of health care, the critical need for change, and the future we want. Patient-centered, p
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Personalized Medicine: Innovation to Clinical Execution

With personalized medicine, researchers use extremely sophisticated data analysis to separate a large population of people who u
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