Over the past year, the NAM Accelerating Clinical Knowledge Generation and Use meeting series, which was sponsored by PCORI and held under the auspices of the NAM Executive Leadership Network for Continuously Learning Health Care, focused on the institutional capacity and infrastructure needed to facilitate care delivery, care improvement, and new knowledge; ways to accelerate progress through cooperation and sharing across organizations; and approaches to steward system-wide progress toward continuous learning and improvement throughout health and health care.