Ebola and Zika have reminded the world of how unprepared we are for a major disease outbreak. A significant amount of analysis and reflection followed these crises, including the recommendations from the Commission on a Global Health Risk Framework for the Future convened by the National Academy of Medicine (NAM). These efforts have led to broad consensus on what must be done to better detect, prevent and respond to the next major epidemic—yet far too little action has taken place thus far.